• In many cells AR mediated activation of PLC has

  2023-04-25

  

  In many nuciferine α1-AR mediated activation of PLC has been shown to be the downstream process for NA-induced signalling. The activated PLC initiates subsequent signalling by breakdown of PIP2 to IP3 and DAG (Fisher and Agranoff, 1987) and the process continues. To confirm if such mechanism exists

• br Funding This work was supported by the National

  2023-04-23

  

  Funding This work was supported by the National Natural Science Foundation of China (grant No. 81573664). Thanks to Jing-xian Yang from the Pharmacology Laboratory of Liaoning University of Traditional Chinese Medicine for support with technology and experimental equipment. Disclosure Confl

• br Application of bamboo in the food and pharmaceutical

  2023-04-21

  

  Application of bamboo in the food and pharmaceutical industry For decades, the application of antioxidants in the food and pharmaceutical industry has been widespread. In the past, antioxidants were previously used to control oxidation and retard spoilage but today, many are used because of putat

• Physical and chemical preservatives such

  2023-04-21

  

  Physical and chemical preservatives such as ultraviolet and ɣ-rays irradiation, sulphur and aluminium phosphide fumigation, etc, have been introduced to inhibit the growth of fungi. Nevertheless, due to the potential decomposition reactions and residues, as well as their own potential toxicity, and

• AMP activated protein kinase AMPK is composed of and

  2023-04-21

  

  AMP-activated protein kinase (AMPK) is composed of α-, β-, and γ-subunits [17,18]. Phosphorylation of α-subunit at Thr-172 residue is essential for AMPK activation [17,18]. The serine/threonine kinase coordinates metabolic pathways in response to energy supply and demand [17,18]. Studies have shown

• Circular dichroism CD provides useful information

  2023-04-21

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light Quinidine spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the commonly

• br Conflict of interest statement br Introduction

  2023-04-21

  

  Conflict of interest statement Introduction Human saliva contains many detoxifying and antioxidant Cy3 carboxylic acid (non-sulfonated) like glutathione S-transferase, catalase, peroxidase, aldehyde dehydrogenase (ALDH), etc. [1]. Human salivary ALDH (hsALDH) protects individuals from toxic al

• br Introduction ACK or Activated Cdc Associated

  2023-04-20

  

  Introduction ACK1, or Activated Cdc42-Associated Kinase, located on chromosome 3q, is a ubiquitously expressed non-receptor tyrosine kinase cloned from a human muscarinic receptor antagonists cDNA library (Manser et al., 1993). It was first identified to bind to activated Cdc42, a small Ras GTPa

• br Acknowledgements br Introduction Autoantibodies

  2023-04-20

  

  Acknowledgements Introduction Autoantibodies directed at neurotransmitter receptors and ion channels are pathogenic and/or biomarkers in several autoimmune neurological diseases [1]. For example, autoantibodies directed against voltage-gated potassium channels, the P/Q-type (α1A) voltage-gated

• br Conclusion br Conflicts of Interest Disclosures br

  2023-04-20

  

  Conclusion Conflicts of Interest/Disclosures Acknowledgement This study was funded by the Ministry of Science of the Republic of Serbia (grant #175083). Introduction Myasthenia gravis (MG) is an antibody-mediated, neuromuscular transmission disorder, where the targets are postsynaptic p

• br Experimental section br Conflicts of interest br Acknowle

  2023-04-20

  

  Experimental section Conflicts of interest Acknowledgments This work was partly supported by INSA-Rouen, Rouen University, CNRS, Labex SynOrg (ANR-11-LABX-0029), Région Haute-Normandie. Introduction A key component of the integrated management of key pests such as codling moth (Cydia po

• Apoptosis or programmed cell death

  2023-04-20

  

  Apoptosis or programmed cell death is a function of biochemical mechanisms, which are energy-dependent. It is considered to be a vital component of many processes such as normal cell cycle, immune mechanism, atrophy, embryonic development and toxin-induced cell death (Elmore, 2007). In addition, apo

• Firms are subject to corporate taxation and face either

  2023-04-20

  

  Firms are subject to corporate taxation, and face either an ACE or a CBIT tax scheme. The two tax regimes achieve financing neutrality by treating debt and equity equally, but differ according to whether deduction of capital costs from the corporate tax Epinephrine HCl is allowed or not. While ACE

• Finasteride has been shown to

  2023-04-20

  

  Finasteride has been shown to be a mechanism-based inhibitor of 5AR-2 [9]. Finasteride acts as an alternate substrate for 5AR-2 and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. The NADP-dihydrofinasteride a

• If the lack of specificity and the high

  2023-04-20

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it Adenine HCl may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as limi

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