• To elucidate this relationship we developed a spatial

  2023-02-20

  

  To elucidate this relationship, we developed a spatial model of Ca-influx through N-methyl-D-aspartate receptor (NMDAR), CaMKII/PP1 activation, and AMPAR insertion in a realistic spine geometry. Using this model, we show that i) variables in membrane voltage mediated Ca-influx, particularly the numb

• br Funding br Introduction Plants absorb both

  2023-02-20

  

  Funding Introduction Plants absorb both inorganic nitrogen (ammonium and nitrate) and organic nitrogen (amino acids and peptides) from the soil [1]. The first organic nitrogenous molecule produced from inorganic nitrogen is Gln, whose terminal amino group is successively transferred to make Gl

• The random zero offset of accelerometer and

  2023-02-20

  

  The random zero offset of accelerometer and gyroscope estimated by two-step observation update Kalman filter are shown in Table 2, one group of estimated results is shown in Fig. 3. Contrast with the data from Eq. (23) and the ones from Fig. 3 and Table 2, it can be seen that the random zero offset

• br Discussion Myopathic EMG changes are frequently detected

  2023-02-16

  

  Discussion Myopathic EMG changes are frequently detected in patients with MuSK MG, unlike in AChR MG patients [10]. However, these EMG changes are not always accompanied by myopathic histopathological findings. It has been shown that mitochondrial abnormalities seem to be more prominent in MuSK M

• The cellular mechanism underlying the CGS mediated

  2023-02-15

  

  The cellular mechanism underlying the CGS12066-mediated inhibition of glutamate release from hippocampal nerve terminals through presynaptic 5-HT1B receptors remains to be elucidated. 5-HT1B receptors are coupled to PTX-sensitive G proteins (Gi or Go) that have been shown to inhibit AC activity as w

• Elevated expression of Aurora A and B frequently detected in

  2023-02-13

  

  Elevated expression of Aurora-A and -B frequently detected in a wide variety of human cancers strongly indicate that high expression of these kinases play roles in the development of cancer associated phenotypes. While Aurora-A has been shown to function as an oncogene when over expressed in mammali

• Apoptosis signal regulating kinase ASK

  2023-02-13

  

  Apoptosis signal-regulating kinase 1 (ASK1, also referred to as MAP3K5)(Ichijo et al., 1997) participates in many different stress responses, including apoptosis (Chang et al., 1998, Chen et al., 1999, Ichijo et al., 1997, Kanamoto et al., 2000, Noguchi et al., 2008, Saitoh et al., 1998, Tobiume et

• br Conflict of interest br Acknowledgements br Introduction

  2023-02-13

  

  Conflict of interest Acknowledgements Introduction The mitogen-activated protein kinase (MAPK) pathway is an important intracellular signaling system that regulates diverse cellular functions, such as proliferation, differentiation, and apoptosis [1]. Apoptosis signal-regulating kinase 1 (A

• br Acknowledgement br Introduction Estrogens play

  2023-02-13

  

  Acknowledgement Introduction Estrogens play an important role in the development and progression of breast cancer (McGuire et al., 1976; Clemons and Goss, 2001). 17β-Estradiol (E2), the most biologically active estrogen in breast tissue, functions via its nuclear receptors, estrogen receptor (

• SB742457 Cellular detoxification is an important process tha

  2023-02-13

  

  Cellular detoxification is an important process that helps remove excess oxidants from the cellular environment through endogenous antioxidants or other molecules capable of reduction. One of the key regulators of antioxidant production is the transcription factor, nuclear factor (erythroid-derived

• SU5416 In a recent issue of Minokoshi and colleagues have ad

  2023-02-13

  

  In a recent issue of , Minokoshi and colleagues have added more light to our understanding of the role of hypothalamic AMPK in the regulation of energy balance. Previous seminal work from the same group suggested that AMPK in the PVH might be involved in the modulation of feeding . Here, they show

• WKY and SHR strains have important differences mainly

  2023-02-13

  

  WKY and SHR strains have important differences mainly in their sympathetic status but also in the activity of the RAS. The development of hypertension in SHR is clearly related to an increase in sympathetic activity [51], [11]. In addition, increased renal sympathetic nerve activity led to an increa

• Since the first studies of betaine aldehyde

  2023-02-13

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other exportin as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of attention

• Sperm total motility and hyperactivated motility are mediate

  2023-02-13

  

  Sperm total motility and hyperactivated motility are mediated by PLD-dependent Cy3 maleimide (non-sulfonated) polymerization [20]. Reduction of PIP2 synthesis inhibited actin polymerization and motility, and increasing PIP2 synthesis enhanced these activities. Furthermore, sperm demonstrating low m

• Our initial approach to identify

  2023-02-13

  

  Our initial approach to identify hits was two-pronged and included a high-throughput screening (HTS) campaign of the OSI RGDfK library as well as a virtual screening (VS) campaign, utilizing a publically available crystal structure of ACK1 (PDB code: ). A tolerance for protein flexibility was incorp

15923 records 310/1062 page Previous Next First page 上5页 306307308309310 下5页 Last page