• Cx is a phosphoprotein that is

  2022-03-16

  

  Cx43 is a phosphoprotein that is predominantly phosphorylated in the control state. Cx43 can be phosphorylated by a number of kinases and dephosphorylated by protein phosphatases such as PP1 and PP2A [6], [10]. Posttranslational phosphorylation of Cx43 is thought to influence intercellular coupling

• In a mouse model of hyperhomocysteinemia a risk factor for

  2022-03-16

  

  In a mouse model of hyperhomocysteinemia (a risk factor for the development of vascular dysfunction) it has been shown that myoendothelial communication is enhanced due to increased expression of Cx37 and IK1 Flavin adenine dinucleotide disodium [], allowing the propagation of endothelial signals to

• br Conflict of interest br Introduction Milk and

  2022-03-16

  

  Conflict of interest Introduction Milk and dairy products are nutritious foods that provide lactose, calcium, phosphorous, magnesium and proteins, among other nutrients, which have been reported to have a fundamental role in bone development and healthy diets. An adequate consumption of dairy

• br Experimental Procedures Information on

  2022-03-16

  

  Experimental Procedures Information on the materials used in this study and the details of how the in vivo and in vitro assays were performed are provided in Supplemental Information. Acknowledgments This research was supported by the National Research Foundation of Korea (NRF) grant funded b

• A mutation in stearoyl coenzyme A desaturase

  2022-03-16

  

  A mutation in stearoyl coenzyme A desaturase 1 gene was reported to reduce sebum production and monounsaturated fatty acids (MUFA) synthesis in mice, which was accompanied with impaired clearance of gram-positive bacteria-induced skin infection (Georgel et al., 2005). Interestingly, gram-positive ba

• On the other hand histone deacetylase

  2022-03-16

  

  On the other hand, histone deacetylase inhibitors can accelerate inflammation resolution by promoting the externalization of AnxA1, a main ALX/FPR2 agonist, with concomitant inhibition of cytokine gene expression in mouse macrophages [30]. Thus, our present results provide an additional mechanism, i

• br Author contributions br Acknowledgements The work

  2022-03-15

  

  Author contributions Acknowledgements The work was supported in part by Natural Science Foundation of China (31601995, 31501028) and an internal research grant of Jianghan University (14042). The authors thank HY of Jingchu University of technology for revising the manuscript. Introduction

• rgs protein br Materials and methods br Results br Discussio

  2022-03-15

  

  Materials and methods Results Discussion Numerous studies have identified important roles for HIF-1α in cellular function and dysfunction through its transcriptional activity [4]. A few studies have reported that HIF-1α is translocated to the mitochondria in human and mouse cancer cell line

• br Conclusion The present study provides evidence to suggest

  2022-03-15

  

  Conclusion The present study provides evidence to suggest that the ingestion of acetate as a way to augment cellular pools of acetyl-CoA and influence histone acetylation, does not replicate the epigenetic effects of the prebiotic B-GOS®. Furthermore, acetate feeding does not influence olanzapine

• The involvement of prostaglandins on the effects induced by

  2022-03-15

  

  The involvement of prostaglandins on the effects induced by 1-nitro-2-phenylethane is similarly unlikely because vasorelaxation was not changed by indomethacin [20]. The inhibition of adenylyl cyclase with MDL-12330A [21] or cAMP-dependent protein kinase A with KT-5720 [22] also did not interfere wi

• Although it is currently unknown why the

  2022-03-15

  

  Although it is currently unknown why the longer splice variant found in the human has not been found in any other species, similar results have been reported for other receptors, including the 740 Y-P receptor splice variant ERbeta2 identified in human and primate, but not other species (Sierens, e

• br Animal models of NASH The

  2022-03-15

  

  Animal models of NASH The human NAS system (see above) is largely reproducible in NAFLD mouse models [37] and, therefore, has been increasingly applied in the preclinical assessment of liver histological responses to test compounds. In general, the NAS system is well suited for this purpose, alth

• Dendritic damage and loss of synaptic connections correlate

  2022-03-15

  

  Dendritic damage and loss of synaptic connections correlate with cognitive decline in HAND patients. Synapse loss induced by HIV proteins occurs early and via a different signaling pathway from that leading to neuronal death (Kim et al., 2008), suggesting that synapse loss might be a mechanism to re

• br Significant efforts are currently

  2022-03-15

  

  Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) Cy3 azide receptor hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-containing

• Diabetes induced damage results in peripheral

  2022-03-15

  

  Diabetes-induced damage results in peripheral nerve pathology that Tovok correlates with clinical signs and symptoms. Nerve injury that results in structural changes can be measured through clinical neurological assessment, quantitative sensory testing, nerve conduction studies, and peripheral nerve

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