• Cx mimetic peptides short synthetic peptides corresponding t

  2022-02-22

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino Pyocyanin sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in a concent

• DAMPs are endogenous danger signals

  2022-02-21

  

  DAMPs are endogenous danger signals that can initiate and perpetuate a noninfectious promotion information during cell death [23]. HMGB1 is a well-studied nuclear DAMP in various types of regulated necrosis and has been implicated in the pathogenesis of infection and sterile inflammation. Our curren

• Our results demonstrated that most of the HUA rings

  2022-02-21

  

  Our results demonstrated that most of the HUA rings incubated with 100 μM TBT do not have the capacity to contract in the presence of 5-HT or exhibit very low contractions in comparison to the control. Only 23.3% of the HUA rings were able to contract. These results seem to indicate that there may b

• Recently the spectrin cytoskeleton a

  2022-02-21

  

  Recently, the spectrin cytoskeleton, a deformable actin-associated network, has been identified as a modulator of Yki function, potentially acting both apically and basally in different cell types [75•, 76•, 77•]. Several mechanisms have been proposed, including regulation via Crb/Ex tethering [], t

• HOs can be found in both plants and animals and

  2022-02-21

  

  HOs can be found in both plants and animals and they are evolutionarily conserved proteins [8]. There are two HO isoenzymes: inducible heme oxygenase-1 (HO-1) and constitutive heme oxygenase-2 (HO-2) encoded by different genes [9,10]. Biosynthesis of a stress-inducible HO-1 can be triggered by a va

• Barthi et al previously showed that curcumin inhibits IKK co

  2022-02-21

  

  Barthi et al.[43] previously showed that curcumin inhibits IKK complex activity and thus IκBα phosphorylation as well as the p65 nuclear translocation. Those data are in agreement with our results obtained by gel shift assays using GSTP1-1 promoter and consensus NF-κB probes. Moreover, luciferase ac

• To date no studies have demonstrated any effect of

  2022-02-21

  

  To date, no studies have demonstrated any effect of obesity or inflammation on GPR109A expression in adipose tissue. Our findings demonstrate that HFD-induced obesity decreases adipose tissue GPR109A gene expression. Contradictory to our findings in adipose tissue in vivo, Digby et al. report that e

• For several years CXCL had

  2022-02-21

  

  For several years, CXCL17 had been classified as an orphan chemokine, until Maravillas-Montero et al. claimed that orphan G-coupled protein receptor GPR35 is the receptor of CXCL17 [15], [16]. However, no following research has been produced to further explore the function of the CXCL17-CXCR8 (GPR3

• Consistent with previous reports of an association

  2022-02-21

  

  Consistent with previous reports of an association between increased accumulation of cAMP and GLP-1 secretion [25, 44, 45], we hypothesized that Oleoyl-LPI may regulate GPR119 activation and secretion of GLP-1 secretion through the cAMP/PKA/CREB pathway. Pharmacological inhibition of PKA by H-89 was

• Thermal analysis of the NQ peptide was

  2022-02-21

  

  Thermal analysis of the NQ21 peptide was performed with the Solar CM2203 spectrofluorometer. We prepared three 1 μg/mL peptide solutions with different WEHI-539 hydrochloride receptor levels (5.0, 7.4, 8.5) in 0.01 M phosphate buffers. Each solution was slowly heated up from 28 °C to 54 °C with a s

• Recent research reveals that human alkyladenine DNA glycosyl

  2022-02-21

  

  Recent research reveals that human alkyladenine DNA glycosylase (hAAG) is an important protein enzyme which can specifically recognize and excise a variety of alkylated purines and deoxyinosine from DNA [12]. hAAG plays pivotal roles in maintaining genomic integrity, and it is involved in HBC recept

• The standard model of stress

  2022-02-18

  

  The standard model of stress postulates the activation of both the sympathoadrenomedullary axis and the hypothalamo-pituitary-adrenocortical axis. Long-term activation of either neuroendocrine axes has been shown to be harmful [12]. Short-term activation of the sympathoadrenomedullary axis is used t

• Introduction The West syndrome or

  2022-02-18

  

  Introduction The West syndrome or epilepsy with epileptic spasms (ES) is an epileptic encephalopathy in early infancy with probable seizure-related developmental regression. According to the United Kingdom Infantile Spams Study (UKISS), common causes of infantile spasms include hypoxic-ischemic enc

• cAMP is a key secondary messenger which transduces extracell

  2022-02-18

  

  cAMP is a key secondary messenger which transduces extracellular signals at glucagon receptors to intracellular effector molecules. cAMP-protein kinase A (PKA) pathway increases the gene expression of enzymes including phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) whic

• In the last years a plethora of studies

  2022-02-18

  

  In the last years, a plethora of studies overstepped the classic concept of the ENS as purely modulator of GI secretion and motility, focusing on its potential as source of substances acting on immune cells and consequently involved in the control of local inflammatory events, as in the Inflammatory

16572 records 507/1105 page Previous Next First page 上5页 506507508509510 下5页 Last page