• All the compounds and were assayed for their potential cytot

  2021-09-03

  

  All the compounds –, , , –, , – and – were assayed for their potential cytotoxicity at a single dose of 10 µM on Huh7 cells. Interestingly, all compounds proved to be non toxic, with the exception of and which exhibited high cellular toxicity and therefore were excluded from further experiments (a

• GPR co localizes with ghrelin in the duodenum gustducin in

  2021-09-02

  

  GPR120 co-localizes with ghrelin in the duodenum [17], α-gustducin in the small intestine and type II taste bud cells 18, 19, neuropeptide Y centrally in the arcuate nucleus [20] and glucagon-like peptide 1 (GLP-1) in the colon and circumvallate papillae taste bud cells 6, 21, 22. Interestingly GPR1

• In addition to their functional activation of GPR A compound

  2021-09-02

  

  In addition to their functional activation of GPR109A, compounds of the pyrazolopyrimidine class also enhanced the binding of nicotinic Ac-Endothelin-1 (16-21), human to the receptor. For instance, increased the binding of H-nicotinic acid to the receptor (black curve) in a concentration-dependent

• br GnRH receptor expression is altered within

  2021-09-02

  

  GnRH receptor expression is altered within GnRH neuronal cells Kisspeptin failed to stimulate GnRH expression in our line of GT1-7 cells. Instead, we have found that kisspeptin increased the expression of the GnRH receptor in these TRAM-34 (Sukhbaatar et al., 2013). Based on the results of exper

• Gentamycin Sulfate Acarbose and voglibose the classic glucos

  2021-09-02

  

  Acarbose and voglibose, the classic α-glucosidase inhibitors, were clinically used to inhibit α-glucosidase activity for the treatment of type 2 diabetes. However, the intake of these drugs may cause some undesirable gastrointestinal side effects and weight gain (Xu et al., 2015). The synthetic drug

• Most excitingly we found the increased

  2021-09-02

  

  Most excitingly, we found the increased δ-cells hold the ability to trans-differentiate into β-cells in T1D mice. It has been shown that after near-total β-cell loss, juvenile mice display δ-to-β-cell conversion to recover diabetes, involving de-differentiation, proliferation and re-expression of is

• Gli signaling pathways play critical roles in embryonic

  2021-09-02

  

  Gli signaling pathways play critical roles in embryonic and postnatal lung development [22]. Many reports suggest that wound healing and fibrotic diseases involve activation of pathways used during development [23]. In the adult lung, Gli signaling activity measured by Gli1 expression is restricted

• Various strategies have been pursued

  2021-09-02

  

  Various strategies have been pursued in the search for GIPR antagonists. Antibodies raised against both GIP(1–42) [14], [15] or the GIPR [16], [17], a small molecule antagonist [18], amino RG7388 substitutions of GIP(1–42) [19], and various GIP(1–42) truncations and modifications such as e.g. Pro3(G

• Further we examined the degradation of

  2021-09-02

  

  Further, we examined the degradation of Cx43. Autophagy and the proteasome system have previously been implicated in Cx43 degradation (Falk et al., 2014). DEX inhibited communication between influenza a virus by promoting the degradation of Cx43 through autophagy in osteocytes (Gao et al., 2016). I

• In the present studies we found that genistein

  2021-09-02

  

  In the present studies, we found that genistein did not antagonize fMLF-induced Ca2+ mobilization in FPR1-HL60 hippo pathway and human neutrophils. Thus, the previously reported inhibitory effect of genistein on fMLF-stimulated degranulation, aggregation, and reactive oxygen species (ROS) productio

• The activation of GPR FFA signaling triggers the PLC PIP

  2021-09-02

  

  The activation of GPR40/FFA1 signaling triggers the PLC/PIP2 signaling pathway and results in Ca2+ release from the endoplasmic reticulum (ER). Increased Ca2+ levels may lead to activation of different protein kinases, such as Ca2+/calmodulin-dependent protein kinase type IV, Akt, extracellular sign

• Several small molecules such as erastin and RSL are

  2021-09-02

  

  Several small molecules, such as erastin and RSL3, are reported to induce ferroptosis in both normal and cancer 3 methyladenine [21,22]. We confirmed that erastin-induced growth inhibition is an ideal ferroptosis model for cardiomyocytes. The erastin inhibits the growth of H9c2 cells in a Fe-depend

• WT associated protein WTAP a nuclear protein is first identi

  2021-09-02

  

  WT1 associated protein (WTAP), a nuclear protein, is first identified by Little [6] who noticed its specific interaction with WT1. Besides several essential physiological processes, such as mRNA stabilization [7], eye development [8], m6A methylation [9], mRNA alternative splicing [10] and (±)-CPSI

• br Ubiquitylation of the TGF BMP

  2021-09-02

  

  Ubiquitylation of the TGFβ/BMP pathway components Ubiquitylation is a reversible post-translational modification that is essential in many cellular regulatory mechanisms [20], [21]. During the ubiquitylation cascade, ubiquitin is attached to target proteins through the concerted actions of an E1-

• In summary we hypothesize that

  2021-09-02

  

  In summary, we hypothesize that targeting the A1R–D1R heterotetramer with heteromer-selective drugs might improve safety and efficacy of the pharmacological therapy for RLS and other motor diseases, resulting in fewer side effects than classical drugs developed for targeting monomeric A1R or D1R.

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