• Since cognitive disturbances are core features of PTSD and

  2021-04-12

  

  Since cognitive disturbances are core features of PTSD [3,4], and in some studies COMT Val158/108Met was associated with cognition [10] and hippocampal volume [12], the hypothesis was that carriers of the Met allele will show better cognitive performance compared to Val/Val carriers in PTSD. The ai

• Ten non FH ADH probands fulfilled the diagnostic criteria

  2021-04-12

  

  Ten non-FH ADH probands fulfilled the diagnostic criteria of hyperabsorbers. Table 2 shows the main lipid characteristics of these subjects and of 10 non-hyperabsorber probands used for comparison. There were differences between groups in body mass index, waist circumference and triglycerides. Other

• In rodent models the loss of estrogens through

  2021-04-10

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an Benzoylmesaconitine sale receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxid

• br Discussion We are reporting a cryptic

  2021-04-10

  

  Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in 10-Hydroxycamptothecin exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most common secondary abnor

• Another important consideration with respect to drug conditi

  2021-04-10

  

  Another important consideration with respect to drug conditioning suggested by the present findings is the observation of an attenuated Angiotensin I (human, mouse, rat) on the second extinction trial. Seemingly, if ERK measurements were made following a partial reduction in the conditioned respons

• br Competing interests br Acknowledgments This work was supp

  2021-04-10

  

  Competing interests Acknowledgments This work was supported by grants from Fujian Fujian Provincial Natural Science Foundation (2016J01612). Introduction Cancer is still one of the most serious diseases in the world. According to the World Health Organization (WHO), cancer is the second mo

• In studies directed toward the development of sequence

  2021-04-10

  

  In studies directed toward the development of sequence-specific major-groove binding small Viroptic [11], we desired a non-intercalating molecular scaffold that could direct attached moieties into the major groove. As an initial step toward this goal, we wished to study the DNA binding mode and aff

• The collagen binding membrane proteins discoidin domain rece

  2021-04-10

  

  The collagen-binding membrane proteins, discoidin domain receptors 1 and 2 (DDR1 and DDR2) belong to the family of receptor tyrosine kinase and are expressed in a variety of mammalian cells.7, 8 These transmembrane glycoproteins (∼125 kDa) have been found to be over-expressed or atypically expressed

• Proteins that associate to PCNA are

  2021-04-10

  

  Proteins that associate to PCNA are characterized by having conserved motifs as the PCNA-interacting protein (PIP) motif [29,30], its variant PIP-like motif [31,32] or the APIM motif (Alk B homologue 2 PCNA interacting motif [33,34]); for instance, p21 contains a PIP motif [30], and DNA polymerases

• Converging evidence suggests that reduced glutamate

  2021-04-09

  

  Converging evidence suggests that reduced glutamate transmission in the LS is linked to increased anxiety-like behaviors (Radulovic et al., 1999, Henry et al., 2006, Bakshi et al., 2002, Liu et al., 2004). Therefore, attenuated CRF1 receptor-mediated excitatory transmission in the LS following ASV-t

• Based on the ability of CRF to modulate nociception

  2021-04-09

  

  Based on the ability of CRF to modulate nociception, we hypothesized that stress leads to hyperalgesia by the activation of CRF1 and/or CRF2 receptors in the spinal cord. We tested this hypothesis using an acute forced swim as a widely used and easily reproducible stressor and grip force as a measur

• br The LSCP model and its

  2021-04-09

  

  The LSCP model and its properties In this section, we first introduce the LSCP model in Section 2.1. Some examples of the model are presented in Section 2.2 and basic properties of the model are presented in Section 2.3. Finally, Section 2.4 introduces finite dimensional approximations necessary

• The acetylcholinesterasic activity of exposed animals

  2021-04-09

  

  The acetylcholinesterasic activity of exposed animals, after treatment with diverse concentrations of uranium and following distinct recovery periods, remained unaltered for all species. This finding suggests that uranium, in spite of being a water-soluble metal, does not exert any effect on the sel

• The mechanisms by which coregulators control

  2021-04-09

  

  The mechanisms by which coregulators control the actions of estrogen receptors are still a topic of ongoing research. From studies in cancer cells, we have learned that a large group of coregulators have specific structural motifs that than affect their contact with ER ligand-binding domains (Heery

• br Effects of estrogen on

  2021-04-09

  

  Effects of estrogen on vascular function Atherosclerosis is a chronic inflammatory condition of the vascular wall (Figure 1) that can be converted to an acute clinical event by the induction of plaque rupture or erosion, leading to thrombosis [58]. This perpetuating process is characterized by ph

16562 records 699/1105 page Previous Next First page 上5页 696697698699700 下5页 Last page