• Eleutherococcus senticosus Rupt Maxim Maxim is a shrub

  2020-11-13

  

  Eleutherococcus senticosus (Rupt. & Maxim.) Maxim is a shrub belonging to the Araliaceae, which is commonly distributed in China, Korea, Japan and Russia. It has been traditionally used as folk medicine for the treatment of rheumatism, diabetes, and hepatitis (Nan et al., 2004). Recent phytochemical

• Kluveromyces lactisSimilar to S cerevisiae K lactis is a

  2020-11-13

  

  Kluveromyces lactisSimilar to S. cerevisiae, K. lactis is a facultative anaerobic respiratory yeast, which lacks Complex I in its mitochondrial respiratory chain. However, both yeasts differ regarding their respiratory-fermentative metabolism as K. lactis exhibits a greater use of the pentose phosph

• Previous studies showed that many steroidogenic enzymes

  2020-11-13

  

  Previous studies showed that many steroidogenic enzymes act when the enzyme binds to the cofactor first [30]. In the present study, we showed that HPTE inhibited both AKR1C14 and RDH2 in a mixed mode when cofactor was used. This indicates that HPTE interferes with cofactor-binding residues although

• Uracil residues incorporated into DNA exist transiently sinc

  2020-11-13

  

  Uracil residues incorporated into DNA exist transiently since they are subject to removal by the multi-step uracil-initiated DNA GSK343 excision repair (BER) process [2], [14]. In E. coli, uracil-DNA BER is initiated by uracil-DNA glycosylase (Ung), which catalyzes the hydrolytic cleavage of the N-

• Studies carried out with LTRAs before the identification of

  2020-11-13

  

  Studies carried out with LTRAs before the identification of the CysLT2R, showed a controversial picture, as results that suggest a role for cysteinyl-LTs in the expansion of ischemic damage and in cardiac dysfunction during reperfusion [5], [68], [69] were evenly balanced by others suggesting that t

• br Material and methods br Results br Discussion In

  2020-11-13

  

  Material and methods Results Discussion In the present study, twenty strains of Y. enterocolitica were analyzed for their inhibitory potential on cysteine proteases. Five of these strains belonged to bioserotype 4/O:3, which is distinguished for its pathogenicity towards humans. The rest of

• RGFP966 Recently it was reported that Crm is

  2020-11-13

  

  Recently, it was reported that Crm1 is linked to spindle pole body (SPB) by Spc72 in RGFP966 yeast [9]. Spc72 and Spc110 are two specific receptors of γ-tubulin complex (Tub4), which target Tub4 to SPB and mediate the nucleation of microtubules from SPB [20]. It was found that disrupting the interac

• br Experimental section br Results br Discussion In our prev

  2020-11-12

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised dantrolene sodium did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a pat

• Our conclusion is in disagreement with that of a recent

  2020-11-12

  

  Our conclusion is in disagreement with that of a recent paper by Park et al. [10], which suggests that nitric oxide (NO) inhibition of VHL recruitment occurs by nitrosylation of the 520 cysteine in HIF-1α, and that SNAP does not directly inhibit hydroxylation of HIF peptide by HPH-2. Although this d

• 2510 Based on the above we hypothesized that

  2020-11-12

  

  Based on the above, we hypothesized that a PROTAC strategy would be effective to induce CK2 protein degradation. Herein reported is an approach for the preparation of novel PROTACs via “click reaction” for degradation of CK2 protein (Fig. 2). Importantly, “click reaction” is a very facile, selective

• Cholesterol homeostasis is maintained through a

  2020-11-12

  

  Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The Folinic acid of cholesterol from the intestine constitutes the central part of cholesterol homeostasis in the body [41]. In particul

• br Materials and methods br Data and statistical

  2020-11-12

  

  Materials and methods Data and statistical analysis The results were expressed as mean ± SEM. One-way analysis of variance (ANOVA), followed by Bonferroni's post-test or unpaired Student's t-test were used to determine significant differences between groups. The program used for statistical an

• In rodents but not humans

  2020-11-12

  

  In rodents but not humans, two splice variants of Chk are identified as Ntk and Ctk, which possess and lack the N-terminal unique domain, respectively. While Ctk is abundantly expressed in the brain, Ntk is selectively restricted to myeloid and lymphoid cells, especially megakaryocytes [31]. This ra

• Arsenic is an endocrine disruptor

  2020-11-12

  

  Arsenic is an endocrine disruptor with estrogenic activity. Further study has shown that arsenic exposure can significantly increase the expression of estrogen receptor-related genes, steroid metabolism-related enzymes and lung cancer-related genes in the lung tissues of female mice on the occurrenc

• Recent pharmacological and clinical studies suggested that e

  2020-11-12

  

  Recent pharmacological and clinical studies suggested that estetrol (E4) should also be considered as an interesting candidate for MHT (Abot et al., 2014; Mawet et al., 2015). E4 is naturally produced from E2 and estriol (E3) via 15α- and 16α-hydroxylase by the human fetal liver during pregnancy and

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