• LTD and LTC cause contraction in

  2020-08-05

  

  LTD4 and LTC4 cause contraction in the rat stomach and these contractions are sensitive to CysLT1 receptor antagonists (Goldenberg and Subers, 1983, Miura et al., 1992, Miyata et al., 1995). However, effects of other leukotrienes in the gastric contraction and inhibitory effects of potent, selective

• As shown in a previous

  2020-08-05

  

  As shown in a previous report (Donatti and Leite-Panissi, 2011), microinjection of CRF into the BLA or CeA of the guinea pig increased the duration of TI episodes compared to control episodes (Fig. 2A–D). However, when the microinjection of CRF into the BLA or CeA was preceded by the injection of CP

• The other manuscript utilized a candidate gene approach to

  2020-08-05

  

  The other manuscript utilized a candidate gene approach to evaluate olaparib in Ewing sarcoma cells (Brenner et al., 2012). The authors again showed increased sensitivity of 3 ES cell lines to olaparib as opposed to an osteosarcoma and rhabdomyosarcoma cell line. In addition, EWS–FLI1 gene transfer

• Death associated protein kinase DAPK a known apoptosis

  2020-08-04

  

  Death-associated protein kinase (DAPK), a known apoptosis regulator, is shown to be up-regulated in atherosclerotic lesions (Arab et al., 2008). DAPK up-regulation leads to increased cell turnover and arterial wall instability, which provides increase susceptibility to LDL Estradiol 17-(β-D-Glucuron

• When considering that virus persistence enhances T cell agin

  2020-08-04

  

  When considering that virus persistence enhances T cell aging, it is notable that NRON has been found to modulate HIV latency by both NFAT-dependent (Imam et al., 2015) and NFAT-independent (Li et al., 2016) mechanisms. It is also intriguing that episodic reactivation of HIV latency is similarly acc

• At least with endothelin receptors most work to

  2020-08-04

  

  At least with endothelin receptors, most work to date has focused on heterodimerization of ETA and ETB receptors, rather than heterodimerization of endothelin receptors with receptors that bind other ligands. However, multiple combinations of receptor heterodimers have been described over the past 2

• Tibolone is also efficacious on bone

  2020-08-04

  

  Tibolone is also efficacious on bone in elderly women and induces a clear reduction in bone turnover markers [50], [51]. Rymer et al. showed that, after 10 years of treatment with tibolone, the difference in bone mineral density compared with a placebo group was more than 12% for both lumbar spine a

• Estradiol the predominant circulating estrogen in

  2020-08-04

  

  Estradiol, the predominant circulating estrogen in humans, it is mainly secreted by the granulosa cells of the ovarian follicles, and the corpora lutea, by the mechanisms indicated above. On the other hand, estretrol is synthesized exclusively during pregnancy by the fetal liver and reaches maternal

• br Results br Discussion In this study we elucidate how

  2020-08-04

  

  Results Discussion In this study, we elucidate how cell-secreted, soluble ECDs of DDR1 and DDR2 inhibit collagen fibrillogenesis and enhance matrix mineralization for ECM endogenously generated by the cells. Using similar experimental approaches, in our earlier work we had demonstrated that ki

• Apocynin receptor Another multi subunit RING containing

  2020-08-04

  

  Another multi-subunit RING-containing ligase is the Fanconi anemia (FANC) E3. There are at least 13 complementation groups associated with this disease, and Apocynin receptor corresponding to eight complementation groups are components of the FANC ubiquitin ligase, including a RING-type protein (Fa

• GLP also showed cardioprotective effects i

  2020-08-04

  

  GLP-1 also showed cardioprotective effects (i.e., infarct size reduction and ejection fraction improvement) in experimental models of myocardial ischemia-reperfusion injury by suppressing caspase-3 activation and preventing apoptosis of cardiomyocytes [[50], [51]]. Of note, such a cardioprotection w

• br A proposed new model of interference sensitive

  2020-08-04

  

  A proposed new model of interference sensitive meiotic recombination pathway In current models of meiotic recombination (Fig. 2), RAD51 and DMC1 facilitate 3′ single end invasion following DSB formation by SPO11. Using the invading 3′-end as a primer and one strand of a non-sister TKI258 as a te

• MS436 br Introduction Initially nitrogen mustards

  2020-08-04

  

  Introduction Initially, nitrogen mustards (NM) are used as an important military vesicant agent. NM can cause skin inflammation, blisters, and ulcers, as well as eye and respiratory tract damage, with no effective treatment. One of the commonly accepted mechanisms of NMs that causes tissue damag

• br Materials and methods br

  2020-08-03

  

  Materials and methods Acknowledgements Supported by CiberNed’s intramural program (Ref. No. PI2016/02) and by grants from Spanish Ministerio de Economía, Industria y Competitividad (BFU2015-64405-R, and SAF2017-84117-R; they may include FEDER funds). Introduction Corticotropin-releasing fa

• Carmofur br Materials and methods br Results br Discussion T

  2020-08-03

  

  Materials and methods Results Discussion The aim of the studies described in this paper was to identify determinants of the sensitivity of human colorectal cancer and NSCLC cell lines to the ZD2767 ADEPT system. In particular, the role of DNA–DNA interstrand cross-linking and TP53 status we

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