• br Materials and Methods br Author

  2019-07-02

  

  Materials and Methods Author Contributions Conflicts of Interest Acknowledgments This work was sponsored by the National Natural Science Foundation of China (81802517), the Integrated Traditional Chinese and Western Medicine of Shanghai (ZHYY-ZXYJHZX-1-03), the Clinical Research Program

• Cantharidin is a natural element extracted from blister beet

  2019-07-02

  

  Cantharidin is a natural element extracted from blister beetles, and has been proven to be effective in cancer [16]. NCTD, the demethylated analog of cantharidin, has been synthesized and been shown to have an equal anti-cancer effect with fewer side effects than cantharidin [39]. It was confirmed t

• Since OH PGE is a moderately selective

  2019-07-02

  

  Since 1-OH-PGE2 is a moderately selective EP4 agonist which could bind to mouse EP3 and EP4 with a relatively similar affinity (Kiriyama et al., 1997), we have used a highly selective EP4 agonist CAY10580 to evaluate the involvement of EP4 activation in PGE2-facilitated EP4 internalization and recyc

• Contrary to the downregulation of S PR family GPCRs

  2019-07-02

  

  Contrary to the downregulation of S1PR family GPCRs, CLL cells have increased mRNA expression of the lysophosphatidic Radicicol structure (LPA) family receptors LPAR1, LPAR3 and LPAR4 compared to normal B cells [47]. Increased LPAR1 mRNA has been shown to be associated with more aggressive disease

• Mulan protein level is regulated with conditions that

  2019-07-02

  

  Mulan protein level is regulated with conditions that stimulate mitophagy such as treatment of fluvastatin sodium with CCCP [12]. We found that exogenously expressed GFP-GABARAP and RFP-Mulan could co-precipitate and co-localize in mammalian cells and the degree of co-localization increased when the

• South Africa was the first African

  2019-07-01

  

  South Africa was the first African country to implement the seven-valent pneumococcal conjugate vaccine (PCV7) in its routine infant immunisation programme (in 2009), with the novel schedule aligned to WHO\'s recommended Expanded Programme on Immunisation (EPI)—ie, a 2 + 1 schedule with doses at age

• br Acknowledgments br Introduction Since the first

  2019-07-01

  

  Acknowledgments Introduction Since the first hospice was established in the United Kingdom in the late 1960s, the use of hospice and palliative care has become popular worldwide. In developed countries, hospice and palliative care are now used for services ranging from in-patient to community

• br Signal averaged electrocardiography SAECG SAECG is

  2019-07-01

  

  Signal-averaged electrocardiography (SAECG) SAECG is a high-resolution electrocardiographic technique developed in the 1970s for detecting patients who are prone to SCD after MI. It is based on the theory that lethal ventricular arrhythmias leading to SCD often have a reentrant mechanism. Reentry

• Harringtonine structure Nakai et al showed that RTc and

  2019-07-01

  

  Nakai et al. showed that RTc and Tpeak-end dispersion can be used to evaluate the spatial distribution of myocardial repolarization [15,16]. We measured RTc and Tpeak-end dispersion in the acute and chronic periods in the case reported herein. Both variables were increased during the acute period af

• Another mechanism is that J waves represent a

  2019-07-01

  

  Another mechanism is that J waves represent a repolarization abnormality where J waves are created by the transmural voltage gradient [16]. During myocardial ischemia, the membrane ionic currents are known to be augmented, in turn augmenting the transient outward current (Ito). Augmented Ito would r

• br Discussion We herein report a case of

  2019-07-01

  

  Discussion We herein report a case of inappropriate shock therapy that was caused by T-wave oversensing and that occurred when the patient had sinus tachycardia and was squatting. Several methods were considered to troubleshoot this problem. We decreased the sensitivity and increased the NID and

• Next we evaluated the interatrial and interatrioventricular

  2019-07-01

  

  Next, we evaluated the interatrial and interatrioventricular synchrony because a long contraction time between the right and left atria was observed during the SSA procedure, dissection of the atrial septum, and patch closure. We were primarily concerned with determining whether the timing of the le

• br Discussion The excimer laser

  2019-07-01

  

  Discussion The excimer laser generator and the laser sheath allow for the extraction of leads while freeing them from the site of adhesion by making use of photoablation induced by the energy of ultraviolet rays. Since its approval in 1997 by the US Food and Drug Administration, the use of excime

• Programmed death ligand PD L expression is

  2019-07-01

  

  Programmed death ligand 1 (PD-L1) expression is a characteristic feature of EBV-associated malignancies. Research has shown that an increase of PD-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Preliminary data from a phase Ib study, KEYNOTE-028, showed

• The miR signature of exosomes

  2019-07-01

  

  The miR signature of exosomes isolated from bulk prostate cancer Spectinomycin hydrochloride hydrate molecular (Fig. 1A, blue cells) and from their cancer stem cell compartment (Fig. 1A, green cells), display high levels of miR-21, miR-30 and miR-218 [23] (Fig. 1A, blue arrow). miR-21 and miR-30 ha

16539 records 1044/1103 page Previous Next First page 上5页 10411042104310441045 下5页 Last page