• Introduction The human epidermis is renewed monthly and dail

  2018-11-12

  

  Introduction The human oxytocin receptor is renewed monthly, and daily occurring wounds need timely repair. The processes involved in this regeneration and repair rely on epidermal stem cells, which generate colonies known as holoclones (Barrandon and Green, 1987; Pellegrini et al., 1999a; Rochat

• We identified CaMKII as a downstream target of

  2018-11-12

  

  We identified CaMKII as a downstream target of NMDA receptors activated in NPCs following TLQP-62 treatment. CaMKII can associate with NMDA receptors and ultimately sustain its activation state (Bayer et al., 2001). Supporting our novel findings for a role of CaMKII in neurogenesis is a study showin

• Oct Sox and Nanog constitute the core transcriptional networ

  2018-11-12

  

  Oct4, Sox2, and Nanog constitute the core transcriptional network of pluripotency. Acting together, these genes regulate self-renewal as well as the early stages of cellular differentiation both in vivo and in vitro (Boyer et al., 2005; Wang et al., 2006; Masui et al., 2007). Nanog expression is res

• br Materials and methods br

  2018-11-12

  

  Materials and methods Results Discussion The main goal of current investigation was to study the role of oxygen in the maintenance of LESC phenotype under conditions of biochemically undefined and a serum-free highly defined growth environment. The oxygen concentrations used in the present

• br Discussion Generating neural stem cells from

  2018-11-12

  

  Discussion Generating neural stem buy SB525334 from hESCs and iPSCs has been successfully achieved by a number of groups (Elkabetz et al., 2008; Falk et al., 2012; Koch et al., 2009; Nemati et al., 2011). However, the simplicity and retained – or even enhanced – differentiation versatility combin

• To confirm iPS identity and purity we

  2018-11-12

  

  To confirm iPS identity and purity, we checked embryonic stem cell makers, Tra-1-81 (Fig. 2A) and Tra-1-60 (not shown) by live staining and found all PD173074 are Tra-1-81 positive. Acknowledgment The project described was supported by Award Number I21BX002215 (WX) from the Biomedical Laborator

• In addition recent findings indicate that the

  2018-11-09

  

  In addition, recent findings indicate that the majority of in vitro expanded cells undergo apoptosis upon implantation (Stegen et al., 2016). A cause may be the need to instantly adjust to a compromised environment, since current culture conditions represent a rather non-physiological and abundant n

• br Introduction In mammalian testes spermatogonial stem cell

  2018-11-09

  

  Introduction In mammalian testes, spermatogonial stem cells (SSCs) are a rare subset of the undifferentiated spermatogonial population that is tasked with providing continuity to the spermatogenic lineage (Oatley and Brinster, 2008, 2012). In addition, SSCs possess regenerative capacity, and foll

• A similar law of the shear module variation

  2018-11-09

  

  A similar law of the shear module variation in the antiplane problem for a system of perfectly bonded wedges was used to construct singular solutions in Ref. [12]. Additionally, this article suggested an approximate method for determining the order of singularity in wedge-like areas, based on a piec

• Our findings suggest that low

  2018-11-09

  

  Our findings suggest that low-income Hispanic men may be uniquely at risk for parenting-related weight gain. While we are not able to identify the social mechanisms for this difference, other literature offers suggestion on why this may be the case. First, prior work has shown that acculturation pla

• High levels of environmental exposure

  2018-11-09

  

  High levels of environmental exposure to peanut due to household consumption during infancy have been related with sensitization (Fox et al., 2009). There is a positive correlation between high peanut consumption and the presence of peanut proteins in the house dust (Brough et al., 2013; Trendelenbu

• br Heating Up Immunologically Cold Tumours

  2018-11-09

  

  Heating Up Immunologically Cold Tumours With an Oncolytic Virus As discussed our immune systems have evolved elaborate mechanisms to react against invading pathogens and rapidly mount immune responses to eliminate the pathogen and in some instances, the cells they infect. OVs are natural pathogen

• Because only transient exposure of melanoma cells to

  2018-11-09

  

  Because only transient exposure of melanoma thip to pevonedistat is sufficient to irreversibly arrest melanoma cells with the majority of cells undergoing senescence, and this occurs only in malignant melanoma cells, targeting the CRL4CDT2 ubiquitin ligase is an especially attractive therapeutic ap

• It is technically challenging to

  2018-11-09

  

  It is technically challenging to extract proteins of interest from bone due to the abundance of collagens and minerals. A pilot study using HCl/Urea extraction identified 119 proteins in OA subchondral bone with only 7 proteins shared between the low and high damage regions. This data suggests that

• potassium phosphate monobasic In this issue of Matsumoto et

  2018-11-09

  

  In this issue of , Matsumoto et al. report the second clinical trial of nationally-regulated encapsulated porcine islet xenotransplantation, conducted in Argentina (). From their previous experience, the authors speculated that a large islet mass was susceptible to injury from oxygen and/or nutrient

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