br Methods br Results br Discussion The structural and funct

2018-10-20

Methods Results Discussion The structural and functional immaturity of the differentiated cardiomyocytes are major obstacles for developing hPSC-VCM-based cell replacement therapies (Kong et al., 2010; van den Heuvel et al., 2014). Although a number of studies showed that the overall matura

Identification of the key populations that give rise to each

2018-10-20

Identification of the key populations that give rise to each wave of embryonic hematopoiesis may provide critical insights into the relationship between primitive and definitive hematopoiesis. However, the surface markers used to isolate adult HSCs and downstream stages have proven unreliable for id

Experimental Procedures br Author Contributions

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in the coding region of the huntingtin (HTT) gene IT15 (MacDonald et al., 1993). The mutation produ

GSK2656157 The aim of this study was to

2018-10-20

The aim of this study was to determine the growth rate of human dental pulp stem GSK2656157 (hDPSCs) under physiological oxygen tension (3%), and to investigate the cell signaling pathways underlying decreased stem cell proliferation during routine culture under ambient oxygen tension (21%). We show

The network shared among L TD OCT SOX and

2018-10-20

The network shared among L1TD1, OCT4, SOX2, and NANOG is highly interesting. Our analysis suggests that the nuclear epigenetic regulator PARP1 and CDK1 are key proteins in the core pluripotency network. Recently, PARP1 expression and PARylation activity were shown to be increased in undifferentiated

Once specified early PGCs are committed and have

2018-10-20

Once specified, early PGCs are committed and have only one fate – that is to become either oogonia that differentiate into oocytes in girls, or spermatogonia, that differentiate into mature sperm in boys. Studies of monozygotic monoamniotic twins where the incidence of discordant primary ovarian ins

It should be noted that the apparently inconsistent results

2018-10-20

It should be noted that the apparently inconsistent results regarding the CD146 status of human ASCs, which were obtained in several studies (Bourin et al., 2013) could at least in part be explained with transitory cells of different sizes, which contain different CD146 protein levels, and with matu

nae inhibitor Overall our robust transcriptome data in

2018-10-20

Overall, our robust transcriptome data in nae inhibitor undergoing hiPSC reprogramming showed dramatic changes in cell signaling pathways, human-specific AS, and ASE during the progressive cell fate change of fibroblasts to iPSCs (Figure 6E). The data will broaden the knowledge of the reprogramming

It remains elusive how ESCs

2018-10-20

It remains elusive how ESCs recruit a larger number of DOs than tissue stem/progenitor Cyt387 during DNA licensing. It is possible that ESCs express a higher level of proteins that mediate DNA licensing. Alternatively, it could be due to their open and hyper-dynamic chromatin structure (Mattout and

br Experimental Procedures br Acknowledgments We thank Drs R

2018-10-20

Experimental Procedures Acknowledgments We thank Drs. Robert Blelloch (UCSF) for the Dgcr8−/− ESCs, Jingyang Feng (Loyola Medical Center) for interpretation of histology results, Tim Townes (UAB) for comments on the manuscript, and the UAB Comprehensive Flow Cytometry Core (P30AR048311 and P30

Finally our findings further support the idea that kinase

2018-10-20

Finally, our findings further support the idea that kinase activity is playing a role in LRRK2-G2019S-induced neuronal dysfunction. Inhibition of LRRK2 kinase activity using LRRK2-IN-1, GSK2578215A, or CZC25146 resulted in partial but significant functional and morphological rescue in homozygous and

We previously reported that D

2018-10-20

We previously reported that 3D retinal tissue differentiated from mESC or mouse iPSC (miPSC) retina can develop a structured ONL of fully mature photoreceptors with outer-segment structures when transplanted into rd1 end-stage retinal-degeneration model mice, possibly by forming synapses with host b

Hello world!

2018-07-29