Once specified early PGCs are committed and have

2018-10-20

Once specified, early PGCs are committed and have only one fate – that is to become either oogonia that differentiate into oocytes in girls, or spermatogonia, that differentiate into mature sperm in boys. Studies of monozygotic monoamniotic twins where the incidence of discordant primary ovarian ins

It should be noted that the apparently inconsistent results

2018-10-20

It should be noted that the apparently inconsistent results regarding the CD146 status of human ASCs, which were obtained in several studies (Bourin et al., 2013) could at least in part be explained with transitory cells of different sizes, which contain different CD146 protein levels, and with matu

nae inhibitor Overall our robust transcriptome data in

2018-10-20

Overall, our robust transcriptome data in nae inhibitor undergoing hiPSC reprogramming showed dramatic changes in cell signaling pathways, human-specific AS, and ASE during the progressive cell fate change of fibroblasts to iPSCs (Figure 6E). The data will broaden the knowledge of the reprogramming

It remains elusive how ESCs

2018-10-20

It remains elusive how ESCs recruit a larger number of DOs than tissue stem/progenitor Cyt387 during DNA licensing. It is possible that ESCs express a higher level of proteins that mediate DNA licensing. Alternatively, it could be due to their open and hyper-dynamic chromatin structure (Mattout and

br Experimental Procedures br Acknowledgments We thank Drs R

2018-10-20

Experimental Procedures Acknowledgments We thank Drs. Robert Blelloch (UCSF) for the Dgcr8−/− ESCs, Jingyang Feng (Loyola Medical Center) for interpretation of histology results, Tim Townes (UAB) for comments on the manuscript, and the UAB Comprehensive Flow Cytometry Core (P30AR048311 and P30

Finally our findings further support the idea that kinase

2018-10-20

Finally, our findings further support the idea that kinase activity is playing a role in LRRK2-G2019S-induced neuronal dysfunction. Inhibition of LRRK2 kinase activity using LRRK2-IN-1, GSK2578215A, or CZC25146 resulted in partial but significant functional and morphological rescue in homozygous and

We previously reported that D

2018-10-20

We previously reported that 3D retinal tissue differentiated from mESC or mouse iPSC (miPSC) retina can develop a structured ONL of fully mature photoreceptors with outer-segment structures when transplanted into rd1 end-stage retinal-degeneration model mice, possibly by forming synapses with host b

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2018-07-29