• br Acknowledgement br Introduction There has been great prog

  2024-12-18

  

  Acknowledgement Introduction There has been great progress in the treatment of autoimmune disease during the past several decades. However, the majority of autoimmune diseases have no known cure. B lymphocytes and autoantibodies play important roles in many autoimmune diseases, including rheum

• DiscoveryProbe inflammation targets Composite soil samples w

  2024-12-18

  

  Composite soil samples were transported to the laboratory and then dried, crushed and passed through a 2mm sieve was. Sample digestion and release of elements method Sposito was performed [15]. Accordingly, taking into account soil moisture to 2g soil samples 12.5ml of nitric acid was added 4M. Samp

• The following are the supplementary data related

  2024-12-18

  

  The following are the supplementary data related to this article. Conflict of interest Acknowledgements Disclosure of interest Introduction Since the introduction of platinum-based chemotherapy, metastatic testicular cancer has become a curable disease and most testicular cancer patient

• Subsequently Palvimaki et al corroborated Ni and

  2024-12-18

  

  Subsequently, Palvimaki et al. (1999) corroborated Ni and Miledi's study by demonstrating that treatment with fluoxetine leads to 43% occupancy of the 5-HT2C receptors. Moreover, the affinity of fluoxetine for 5HT2C receptors (Ki 65 nM) is close to its affinity for 5-HT transporters (Ki 33 nM) (Ni

• In conclusion we have produced

  2024-12-18

  

  In conclusion, we have produced some highly potent inhibitors of P450 in comparison to the standard actin inhibitor KTZ. Also, due to the limited specificity of these compounds against lyase in comparison to the 17α-OHase component, these compounds would be expected to have a major impact on cortic

• Several dehidropregnenolone derivatives functionalized at

  2024-12-18

  

  Several 16-dehidropregnenolone derivatives functionalized at C3, C4, C5 and C6 (Fig. 7) were prepared and evaluated as 5α-reductase inhibitors bearing in mind that after the formation of an enzyme-steroid complex a nucleophilic portion of the enzyme attacks the double bond of the steroid through Mic

• Mistletoe is universal name for various species of parasitic

  2024-12-18

  

  Mistletoe is universal name for various species of parasitic plant which grows attached to and within the branches of host trees such as apple, elm, oak and pine. Mistletoe extract prepared from Viscum album, a species of mistletoe in the family Santalaceae, is generally known as European mistletoe

• br Materials and methods br Results The clinical characteris

  2024-12-18

  

  Materials and methods Results The clinical characteristics of the two selected groups are shown in Table 1. As shown in Table 1, the enzyme activity of ATX in CSF of MS patients (59.90±3.09nmol/min/ml±SEM) was significantly higher (p Discussion Numerous studies have so far shown that ATX ta

• PGR regulation of epithelium stroma

  2024-12-18

  

  PGR regulation of epithelium–stroma crosstalk is proven by numerous studies that utilize genetically engineered mouse models. Before embryo implantation, epithelial PGR mediates the progesterone signal to transcriptionally increase the Ihh levels 13, 15. Epithelial IHH then activates the stromal hed

• Erastin Serum concentrations of acute phase proteins APP and

  2024-12-17

  

  Serum concentrations of acute phase proteins (APP) and of antioxidants have proved to be clinically useful biomarkers of pyometra in different species, including bitches, cows and mares [[11], [12], [13], [14], [15]]. Acute phase proteins are being increasingly used in both human and veterinary medi

• Introduction Plant pathogenic fungi are major

  2024-12-17

  

  Introduction Plant pathogenic fungi are major pathogens in agricultural diseases and the cause of large crop losses worldwide. There are many kinds of plant pathogenic fungi, with various modes of action. For example, Botrytis cinerea (B. cinerea) is the disease pathogen in the economically importa

• It has been well established that shortly after systemic

  2024-12-17

  

  It has been well established that shortly after systemic inflammation, NADPH oxidase and iNOS activity were increased in the SR 2595 receptor and lead to overproduction of reactive oxygen species (ROS) and NO [66]. Moreover, previous studies indicated that Ang II induced an increased level of NADPH

• br The lipoxygenase pathway in diseases of

  2024-12-17

  

  The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic TMPyP4 tosylate receptor and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the fun

• Recent genome wide association studies have

  2024-12-17

  

  Recent genome-wide association studies have indicated SORL1 as a risk factor for AD (Meng et al., 2007, Rogaeva et al., 2007, Wen et al., 2013). SORL1, is expressed in neurons (Yin et al., 2015) and also regulates APP traffic from the cell membrane to the Golgi apparatus. A reduction in its expressi

• br Parkinson s Disease and the immune system Parkinson

  2024-12-17

  

  Parkinson’s Disease and the immune system Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s, which affects 10 million people globally and is characterized by rigidity, bradykinesia, tremors, and gait instability (O’sullivan et al., 2007). The patholo

16557 records 35/1104 page Previous Next First page 上5页 3132333435 下5页 Last page